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Hesperidin is a powerful antioxidant derived from immature citrus fruit.

Hesperidin is a flavonoid, a type of plant pigment with antioxidant properties.¹ ² It is primarily derived from the skin of immature citrus fruit and can also be found in lower concentration in some vegetables and aromatic herbs.³ 

Benefits of Hesperidin

The health benefits of hesperidin were recognized early after it’s discovery; it was initially erroneously identified as a vitamin, “vitamin P”.⁴  

Over the past decade, numerous scientific studies have validated the health benefits of hesperidin.⁵ Research has demonstrated that hesperidin may be effective in supporting immune function.

Hesperidin supports immune function

Hesperidin has been demonstrated to have antimicrobial activity through its antioxidant and radical scavenging properties.⁶

Recent results demonstrate that hesperidin may attenuate influenza A virus (H1N1) induced lung injury⁷ and may also have antiviral properties against SARS-CoV-2.⁸

What to look for in a hesperidin supplement?

Hesperidin is sometimes confused with hesperidin methylchalcone or hesperetin which are in fact structural analogues of hesperidin.

Look at the product label to make sure the active ingredient is hesperidin. You should also take note of the amount of hesperidin: the recommended dose is 1000mg per day taken on an empty stomach.

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References

1 El-Sayed el-SM, Abo-Salem OM, Abd-Ellah MF, Abd-Alla GM. Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain. J Biochem Mol Toxicol. 2008;22(4):268-273. doi:10.1002/jbt.20237

  

Kumar B, Gupta SK, Srinivasan BP, et al. Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats. Microvasc Res. 2013;87:65-74. doi:10.1016/j.mvr.2013.01.00

  

Chanet A, Milenkovic D, Manach C, Mazur A, Morand C. Citrus flavanones: what is their role in cardiovascular protection?. J Agric Food Chem. 2012;60(36):8809-8822. doi:10.1021/jf300669s 

  

Garg A, Garg S, Zaneveld LJ, Singla AK. Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 2001;15(8):655-669. doi:10.1002/ptr.1074

  

Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 2017;57(3):613-631. doi:10.1080/10408398.2014.906382

Iranshahi M, Rezaee R, Parhiz H, Roohbakhsh A, Soltani F. Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin. Life Sci. 2015;137:125-132. doi:10.1016/j.lfs.2015.07.014

Ding Z, Sun G, Zhu Z. Hesperidin attenuates influenza A virus (H1N1) induced lung injury in rats through its anti-inflammatory effect. Antivir Ther. 2018;23(7):611-615. doi:10.3851/IMP3235


8 Bellavite P, Donzelli A. Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits. Antioxidants (Basel). 2020;9(8):E742. Published 2020 Aug 13. doi:10.3390/antiox9080742

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